L. casei – A common probiotic strain

by | Jun 27, 2017 | Probiotic Blog, Probiotic Education, Product Information

L. caseiLactobacillus casei is a probiotic bacterium that can be found in the reproductive and gastrointestinal tracts of humans, as well as cheeses, wines, pickles, and other fermented foods. L. casei has been shown to provide a number of beneficial effects in the body. Managing constipation, preventing diarrhea, assisting in chemotherapy, and reducing the frequency of common respiratory infections are just a few of the many benefits that L. casei can provide.

L. casei helps with general digestion and waste functions in the body

L. casei has the ability to help in managing chronic constipation.1 It is also able to help in alleviating antibiotic-associated diarrhea, and aides in the prevention of C. difficile diarrhea in adults. C. difficile diarrhea is common in people that are taking antibiotics.2

Similar to strains like B. bifidum and S. thermophilus, L. casei can help in managing lactose intolerance. Lactose intolerance is caused by a deficiency of the enzyme that breaks down lactose. This enzyme is called lactase. People can have lactase deficiencies for a number of reasons. Some people are unable to produce lactase because of damage to the lining of their gut, while others were simply born without the ability to produce it. It has the enzymatic capabilities to break down lactose, so it can help lactose-intolerant individuals by serving as a pseudo replacement for lactase.

L. casei can help with common illnesses and serious diseases

Some studies suggest that L. casei has significant anti-tumor capabilities,3 and it could be used as an adjuvant treatment during anticancer chemotherapy.4 An adjuvant treatment is one that modifies or enhances the effect of another treatment. In this case, L. casei supplementation was able to enhance the effects of the chemotherapy treatment so that it could perform its functions more effectively. It has also been shown to be useful as an adjuvant therapy for H. pylori eradication.5

L. casei helped to reduce the frequency of upper respiratory tract infections in athletes training during the winter in a recent study.6 Imagine the impact this could have on college and professional athletic teams where entire seasons ride on the health of individual players. If probiotic strains like L. casei prove to reduce illness rates for star athletes, regular probiotic supplementation seems like a no-brainer. The study was performed on athletes, but the results can be applied to anyone. In fact, here’s a different study where L. casei reduced the rate of respiratory infections in middle-aged office workers.7 If probiotic supplements can help to prevent these kinds of illnesses, you should probably be taking some!

Another study has demonstrated that live L. casei is capable of counteracting the pro-inflammatory effects of E. coli in Crohn’s disease.8 When E. coli causes inflammation in the gut, it can lead to intestinal permeability, or leaky gut. Leaky gut can lead to a variety long-term health problems, like autoimmune diseases, so its ability to counteract this inflammation is a big deal.

As you can see, L. casei can provide your body with a number of important benefits. Keep your eyes peeled for this important strain the next time you’re shopping for a probiotic supplement.

1Koebnick, C., Wagner, I., Leitzmann, P., Stern, U., & Zunft, H. J. (2003). Probiotic beverage containing Lactobacillus casei Shirota improves gastrointestinal symptoms in patients with chronic constipation. Canadian journal of gastroenterology = Journal canadien de gastroenterologie, 17(11), 655–659. https://doi.org/10.1155/2003/654907
2Plummer, S., Weaver, M. A., Harris, J. C., Dee, P., & Hunter, J. (2004). Clostridium difficile pilot study: effects of probiotic supplementation on the incidence of C. difficile diarrhoea. International microbiology : the official journal of the Spanish Society for Microbiology, 7(1), 59–62.
3Fichera, G. A., Fichera, M., & Milone, G. (2016). Antitumoural activity of a cytotoxic peptide of Lactobacillus casei peptidoglycan and its interaction with mitochondrial-bound hexokinase. Anti-cancer drugs, 27(7), 609–619. https://doi.org/10.1097/CAD.0000000000000367
4Baldwin, C., Millette, M., Oth, D., Ruiz, M. T., Luquet, F. M., & Lacroix, M. (2010). Probiotic Lactobacillus acidophilus and L. casei mix sensitize colorectal tumoral cells to 5-fluorouracil-induced apoptosis. Nutrition and cancer, 62(3), 371–378. https://doi.org/10.1080/01635580903407197
5Ahmad, K., Fatemeh, F., Mehri, N., & Maryam, S. (2013). Probiotics for the treatment of pediatric helicobacter pylori infection: a randomized double blind clinical trial. Iranian journal of pediatrics, 23(1), 79–84.
6Gleeson, M., Bishop, N. C., Oliveira, M., & Tauler, P. (2011). Daily probiotic’s (Lactobacillus casei Shirota) reduction of infection incidence in athletes. International journal of sport nutrition and exercise metabolism, 21(1), 55–64. https://doi.org/10.1123/ijsnem.21.1.55
7Shida, K., Sato, T., Iizuka, R., Hoshi, R., Watanabe, O., Igarashi, T., Miyazaki, K., Nanno, M., & Ishikawa, F. (2017). Daily intake of fermented milk with Lactobacillus casei strain Shirota reduces the incidence and duration of upper respiratory tract infections in healthy middle-aged office workers. European journal of nutrition, 56(1), 45–53. https://doi.org/10.1007/s00394-015-1056-1
8Llopis, M., Antolin, M., Carol, M., Borruel, N., Casellas, F., Martinez, C., Espín-Basany, E., Guarner, F., & Malagelada, J. R. (2009). Lactobacillus casei downregulates commensals’ inflammatory signals in Crohn’s disease mucosa. Inflammatory bowel diseases, 15(2), 275–283. https://doi.org/10.1002/ibd.20736


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About the Author

Ryan Bentley, MD, PhD, DC

Co-Founder, Medical Director | Dr. Ryan Bentley is a physician, researcher, author, educator and national speaker. He has a passion for health and helping people live their best possible lives. Dr. Bentley and the doctors Humarian uniquely formulated the Probonix line of probiotics to address the needs of their patients and those suffering from a variety of health conditions.